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What Does Tempest Therapeutics (TPST) Do? — Stock Outlook, Earnings, Market Cap, Related Stocks, and Headquarters at a Glance

Updated August 14, 2026 · First published April 23, 2026

Tempest Therapeutics, traded under the ticker TPST, is a clinical-stage biotech company. Clinical progress in its in vivo cell therapy pipeline, execution of development funding and partnerships, and clinical-data changes at related companies are key items to confirm when interpreting earnings and stock-price outlook.

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🏢 What kind of company is Tempest Therapeutics?

Tempest Therapeutics is a clinical-stage biotech company listed on Nasdaq, developing cell therapy candidates targeting oncology and immunology indications. Because it is pre-commercial, the business centers on R&D, clinical operations, building manufacturing capability, and the execution of external partnerships.

Its core business is the development of an in vivo chimeric antigen receptor T-cell therapy platform and dual-targeting candidates. By combining a cell-targeted delivery approach, the company aims to broaden the scope into oncology and immune-related diseases, with clinical data and manufacturing readiness serving as the focal points of progress.

💰 How does Tempest Therapeutics make money?

Business SegmentRevenue ShareDescription
Cell therapy candidate developmentCoreR&D leveraging an in vivo delivery approach and a dual-targeting construct.
Clinical development partnershipsKey growth pillarIncludes clinical operations and development collaborations with external partners.

For Tempest Therapeutics, candidate development and clinical progress drive business performance more than commercial revenue. Cell therapy candidates sit at the center of R&D, while clinical-operations partnerships and manufacturing technology transfer support development speed and executability. Therefore, alongside revenue flows, the quality of clinical data, the potential for indication expansion, the execution of development partner collaborations, and the sustainability of R&D spending should be reviewed together.

📐 Tempest Therapeutics market cap and company scale

Market capitalization stands at $14.5M, and the headcount has not been publicly disclosed.

As a listed clinical-stage biotech company, Tempest Therapeutics' valuation may shift according to pipeline differentiation, clinical-operations capability, and manufacturing readiness rather than finished-product sales. Compared with peer developers, the safety and efficacy data of its candidates, along with progress in development partnerships, become more important judgment criteria than short-term results. Securing development funding and managing costs take priority over capital returns.

📈 Tempest Therapeutics outlook and share-price trend

1-Year Price Performance
Analyst Consensus
1.0
Sell Hold Strong Buy
Target Price $11 +1108.8% Current $1
52-Week Price Range
$1
Low $1 High $12
vs. low +8.19% vs. high -92.57%

In the near term, candidate readiness for clinical entry, execution of development partnerships, and manufacturing technology transfer are variables that gauge the pace of progress. Over the medium to long term, the core question is whether the in vivo cell therapy delivery platform can expand across multiple oncology and immunology indications, and whether clinical data substantiate the technology's differentiation. Conversely, clinical-result uncertainty, safety signals, regulatory review, R&D funding needs, and biotech capital-market volatility can materially affect pipeline value and the share price.

🎯 Key growth drivers
Clinical progress of in vivo cell therapy candidates
Potential expansion into oncology and immunology indications
Development partnerships and manufacturing capability build-out

⚔️ Tempest Therapeutics core strengths and risks

Cell therapy delivery technology and a multi-indication approach are strengths, but clinical validation and securing development funding remain the key risks.

💪 Core strengths

Dual-targeting approach
The combination of a two-target candidate construct and delivery technology forms the basis of differentiation.
Indication expandability
By targeting both oncology and immunology, the company may broaden its scope if clinical data accumulates.
Development partnerships
External development and manufacturing collaborations provide an execution backbone for clinical operations and production readiness.

⚠️ Key risks

Clinical-result uncertainty
Early and ongoing clinical data may differ from expectations, leading to high volatility in candidate value.
Reliance on capital raising
In this pre-commercial stage, securing additional funding for R&D and operations is critical.
Regulatory and manufacturing execution
Delays in safety review, clinical registration, and manufacturing technology transfer can strain timelines and costs.

🔄 Tempest Therapeutics competitors and related (beneficiary) stocks

A direct competitor developing next-generation T-cell-based immunotherapy is MRKR. Related names include HOWL, which develops treatments for cancer and immune-mediated diseases, and CLRB, which researches targeted oncology therapies. While these companies use different technological approaches, they can be compared within the biotech theme that is sensitive to clinical data, development funding, and regulatory progress.

Competitors
TickerCompanyPriceChangeMarket CapP/EPBRROEDividend Yield
MRKRMRKRMarker Therapeutics Inc$1.21-5.5%$20.2M-1.7-76.87%-
Related stocks (beneficiaries)
TickerCompanyPriceChangeMarket CapP/EPBRROEDividend Yield
HOWLHOWLWerewolf Therapeutics Inc$0.96-2.0%$46.7M-2.9-119.86%-
CLRBCLRBCellectar Biosciences Inc$2.37-1.9%$22.4M-0.7-119.57%-

✅ Tempest Therapeutics investor checkpoints

When evaluating Tempest Therapeutics, investors should look beyond share-price swings and confirm the candidate's progression into the clinical stage and the accumulation of data, execution of development partnerships, and the securing of operating funds. Because a single announcement can heavily impact the enterprise value of a clinical-stage biotech, a checklist-style approach to verification is needed.

CheckpointWhat to verifyCurrent status
🔬 Clinical progressConfirm the flow of candidate registration, patient dosing, and data readouts.Entry-readiness stage
💵 Capital raisingReview operating funds, partnerships, and the feasibility of additional capital.Funding review required
🏭 Manufacturing readinessCheck execution of technology transfer and contract manufacturing collaborations.Partnerships in progress
⚔️ Competitive landscapeCompare clinical progress of cell therapy and targeted oncology developers.Competitive-watch phase

A core risk for clinical-stage companies is that the safety and efficacy of candidates may not be reproduced in subsequent studies. Clinical registration, patient enrollment, manufacturing technology transfer, and regulatory review can take longer than expected, and the failure to secure additional capital in a timely manner can weigh on the sustainability of R&D and operations.

Tempest Therapeutics is a clinical-stage company building its business around an in vivo cell therapy platform and dual-targeting candidates. Because the quality of clinical data, the progress of development partnerships, manufacturing readiness, and funding availability shape enterprise value more than commercial revenue, related announcements and funding conditions should be reviewed together.

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