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ETF Profiles

What Is the IHE ETF? A Complete Guide to Returns, Expense Ratio, Holdings, and Alternative ETFs

Updated May 11, 2026

A sector ETF that concentrates on leading US pharmaceutical stocks. It seeks both the stable profitability and the growth potential of large drugmakers.

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What Is This ETF?

The fund is managed based on the Dow Jones U.S. Select Pharmaceuticals Index to track the performance of the US pharmaceutical industry. Its main holdings are the global pharmaceutical giants that lead new drug development and vaccine production.

Within the healthcare sector, it suits investors who look specifically for the long-term growth potential and dividend stability of pharmaceuticals.

It is a passively managed (index-tracking) ETF launched by iShares in 2006.

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How Does It Invest?

ItemDetails
Tracked IndexDow Jones U.S. Select Pharmaceuticals Index
Management StylePassive (market-cap weighted)
Rebalancing FrequencyQuarterly
Dividend FrequencyQuarterly
Total Expense Ratio0.37%

The fund holds US-listed pharmaceutical companies in order of market capitalization, applying a cap so that no single stock's weighting becomes excessive. This moderates concentration in a handful of large industry names while still following the broader movement of the sector.

  • Pure exposure specialized in the US pharmaceutical sector
  • Portfolio centered on large drugmakers with stable cash flows
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Size and Costs

Assets under management (AUM) stand at $1.6B, and the expense ratio is 0.37% per year.

Whereas VFH and VIS shown in the table represent the financial and industrial sectors, IHE focuses solely on the pharmaceutical industry, which has strong defensive characteristics while also carrying new-drug momentum.

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Performance and Trends

1-Year Price Performance
Dividend & Yield
Dividend Yield 1.31%
Annual Dividend (TTM) $1.43
1Y Return +43.6%
Next Ex-Dividend Date 9/15/2026
52-Week Price Range
$109
Low $75 High $109
vs. low +45.39% vs. high -0.31%

Rising demand for medicines driven by population aging and the launch of innovative new drugs have produced a long-term upward trend. Whenever concerns about an economic slowdown emerge, its appeal as a defensive investment tends to stand out, and it has a tendency to deliver stable performance.

Capital has been flowing into the fund as a lower-volatility alternative to biotech within the healthcare sector, and investor sentiment tends to improve during periods when large drugmakers report solid earnings.

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Strengths and Weaknesses

Its strengths are the stable profitability and defensive nature of large drugmakers, while high concentration in specific stocks and regulatory risk are factors to consider.

💪 Key Strengths

Defensive Characteristics
Medicines are essential consumer goods regardless of economic conditions, so volatility is relatively low even in market downturns.
Stability Centered on Large Caps
By holding large drugmakers with high global market share, investors can expect solid balance sheets and dividend income.
Innovation Growth Potential
The fund includes companies that have the chance for explosive share price gains depending on new drug approvals or clinical trial results.

⚠️ Points of Caution

Stock Concentration Risk
The top few companies account for a very large share of the fund, so their performance has an outsized impact on overall returns.
Government Regulation and Policy
Profitability can react sensitively to changes in the regulatory environment, such as government drug price cuts or patent expirations.
R&D Uncertainty
A failed drug development effort or a delayed clinical trial can cause a sharp drop in an individual company's share price, which may hurt the fund's performance.
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Alternative ETFs and Related Products

FV shown in the table is a strategy that blends multiple sectors. If you want to invest in healthcare as a whole, XLV or VHT can serve as broad alternatives. If you want the more aggressive biotech space, you can consider IBB or XBI. If you want to focus on a specific theme such as medical devices, IHI is also a good option.

Peer Comparison ETFs
TickerNamePriceChangeAUMTotal Expense RatioDividend Yield1Y
VFHVFHVanguard Financials ETF$143.44+3.3%$13.5B0.09%1.64%+12.4%
ONEQONEQFidelity Nasdaq Composite Index ETF$101.48+1.5%$10.4B0.21%0.51%+10.3%
VISVISVanguard Industrials ETF$324.91-1.1%$7.9B0.09%0.94%+10.2%
FVFVFirst Trust Dorsey Wright Focus 5 ETF$72.96-0.6%$3.8B0.89%0.36%+19.5%
IYFIYFiShares U.S. Financials ETF$136.71+3.3%$3.8B0.37%1.42%+11.3%
Top Holdings
TickerNameWeightPriceChangeMarket CapP/EDividend Yield
JNJJohnson & Johnson0.45%$276.32+3.8%$665.2B41.91.93%
LLYLilly(Eli) & Co0.43%$1417.99+0.6%$1.33T46.60.48%
MRKMerck & Co Inc0.09%$150.36+3.9%$371.0B153.62.26%
PFEPfizer Inc0.05%$30.79+2.6%$175.5B44.05.6%
RPRXRoyalty Pharma plc0.05%$67.56+1.8%$38.9B36.01.53%
BMYBristol-Myers Squibb Co0.05%$64.19+4.0%$131.2B14.23.95%
ZTSZoetis Inc0.05%$89.20+7.5%$36.9B14.72.36%
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Investor Checkpoints

These are the key items to verify before investing in IHE. It is important to carefully review the earnings structure specific to the pharmaceutical industry and the concentration in top holdings, and to reflect them in your investment portfolio.

CheckpointWhat to CheckCurrent Status
💵 Total Expense RatioCheck the management fee that comes with a sector-specific ETFMaintained
📊 Top Holding WeightsCheck the concentration of weightings, such as the top two companiesHigh concentration
💊 New Drug MomentumReview the major pipelines and clinical trial schedules of the holdingsOngoing review
⚖️ Policy EnvironmentKeep track of government legislation and regulatory trends on drug pricingMonitoring needed

Pharmaceutical stocks can see very large swings in individual companies depending on patent expirations and new drug approvals. Also, because the weightings of the top companies are high, note that the entire fund can fluctuate sharply depending on their earnings releases.

It is a sector-focused product suited to investors who believe in the stable growth of large US drugmakers. It is useful for adding a defensive character to a portfolio while also expecting the upside of new drug development.

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Disclaimer: This content is for informational purposes only and does not constitute investment advice. All investment responsibility lies with the investor.

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