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What Is the FTXH ETF? A Complete Guide to Returns, Expense Ratio, Holdings and Alternative ETFs

Updated August 17, 2026 · First published August 17, 2026

The First Trust Nasdaq Pharmaceuticals ETF, ticker FTXH, focuses on the US pharmaceutical and biotech industries. Investors should understand its index-based stock selection and quarterly distribution structure, and should also weigh the outlook for related stocks against drug regulation, patent and clinical trial variables, as well as sector concentration risk.

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What Is the First Trust Nasdaq Pharmaceuticals ETF?

The FTXH ETF is a passive product designed to track the performance of the Nasdaq US Smart Pharmaceuticals Index. It selects index constituents from US pharmaceutical and biotech companies, reflecting factors such as profitability, asset efficiency, momentum and cash flow.

Unlike broad market products, it suits long-term investors who want exposure to the growth drivers of the US pharmaceutical industry and are willing to accept the sector-specific risks that come with it.

It is a passive (index-tracking) ETF managed by First Trust.

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How Does the First Trust Nasdaq Pharmaceuticals ETF Invest?

ItemDetails
Tracked indexNasdaq US Smart Pharmaceuticals Index
Management stylePassive index tracking
Rebalancing frequencySemiannual
Distribution frequencyQuarterly
Total expense ratio0.60%
ManagerFirst Trust

The FTXH ETF replicates the index's constituents and weights. From among US pharmaceutical and biotech companies, the index selects stocks by considering liquidity and a range of financial and market characteristics, and it sets weights by reflecting cash flow. As a result, it offers exposure spread across multiple companies in the sector rather than to a single new drug or a single company.

  • A stock selection method that reflects both financial and market characteristics
  • An index-tracking structure concentrated in the pharmaceutical and biotech industries
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First Trust Nasdaq Pharmaceuticals ETF Size and Costs (AUM and Management Fee)

Assets under management (AUM) stand at $1.2B, and the total expense ratio is 0.60% per year.

Trading liquidity and bid-ask spreads can vary with market conditions, so when placing a trade, it is worth checking the trading terms along with the gap between market price and net asset value.

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First Trust Nasdaq Pharmaceuticals ETF Performance and Trends

1-Year Price Performance
Dividend & Yield
Dividend Yield 0.65%
Annual Dividend (TTM) $0.29
1Y Return +47.8%
Next Ex-Dividend Date 9/24/2026
52-Week Price Range
$44
Low $29 High $44
vs. low +50.22% vs. high 0.11%

The performance of the FTXH ETF can be influenced by earnings expectations for the pharmaceutical industry, news on new drug development, the drug pricing environment and regulatory interpretation. Within the sector, large pharmaceutical companies and biotech firms have different business characteristics, so their reactions to market conditions can differ.

Fund flows into the FTXH ETF can reflect the market's views on a preference for defensive sectors, growth expectations and the regulatory environment. Changes in drug pricing policy or patents, as well as geopolitical variables, can affect pharmaceutical companies' earnings outlook and investor sentiment, so related disclosures and industry news should be monitored.

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First Trust Nasdaq Pharmaceuticals ETF Pros and Cons

Sector-specific exposure and index-based diversification are its strengths, but investors should be mindful of sector volatility driven by regulation, patents and development outcomes.

💪 Key Strengths

Sector-specific exposure
It is built around US pharmaceutical and biotech companies, so you can follow the trends of the industry through a single product.
Rules-based selection
It uses an index methodology that considers profitability, asset efficiency, momentum and cash flow together.
Quarterly distribution structure
Because it pays distributions quarterly, you can separately track distributions and changes in principal.

⚠️ Points to Watch

Regulatory changes
Changes in drug pricing policy and approval standards can affect pharmaceutical companies' profitability outlook and share prices.
Patents and competition
Patent expirations, generic drug competition and technological change can weigh on individual companies' product competitiveness.
Sector concentration
Because it is concentrated in the pharmaceutical and biotech industries, it can be more sensitive to industry-specific variables than broad market products.
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First Trust Nasdaq Pharmaceuticals ETF Alternative ETFs and Related Products

In the table, the VFH ETF targets the financial sector, the ONEQ ETF the Nasdaq Composite market, the VIS ETF the industrial sector, the IYF ETF US financials and the FV ETF a concentrated equity strategy, so their underlying exposure and investment objectives differ from those of the FTXH ETF. This comparison table is a reference for broadly contrasting fee burden, asset size and distribution characteristics, and it does not imply a direct substitute for the pharmaceutical industry. Information on listed products in a similar category is limited in the candidate list provided, so it is worth checking each product's prospectus as well.

Peer Comparison ETFs
TickerNamePriceChangeAUMTotal Expense RatioDividend Yield1Y
VFHVFHVanguard Financials ETF$137.32-0.8%$13.5B0.09%1.71%+8.0%
ONEQONEQFidelity Nasdaq Composite Index ETF$100.25-2.8%$10.8B0.21%0.51%+8.1%
VISVISVanguard Industrials ETF$320.75-1.6%$7.8B0.09%0.96%+7.2%
FVFVFirst Trust Dorsey Wright Focus 5 ETF$75.03-1.1%$4.0B0.89%0.35%+22.3%
IYFIYFiShares U.S. Financials ETF$130.94-1.0%$3.8B0.37%1.49%+7.3%
Top Holdings
TickerNameWeightPriceChangeMarket CapP/EDividend Yield
LLYLilly(Eli) & Co0.14%$1417.54+3.2%$1.33T46.60.48%
JNJJohnson & Johnson0.14%$273.20-0.7%$657.7B41.41.96%
ABBVAbbvie Inc0.14%$294.89+1.4%$521.1B83.42.32%
BMYBristol-Myers Squibb Co0.14%$62.48+1.8%$127.6B13.84.06%
MRKMerck & Co Inc0.14%$149.52+2.2%$368.9B152.72.28%
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First Trust Nasdaq Pharmaceuticals ETF Investor Checkpoints

When considering the FTXH ETF, you should check your purpose for gaining pharmaceutical industry exposure, long-term holding costs, distribution policy and currency effects together. Because it is a sector-specific product, changes in regulation and the competitive environment matter for investment decisions as much as news on individual companies.

CheckpointWhat to CheckCurrent Status
Cost burdenCheck the cumulative effect of the total expense ratio over a long holding periodCheck disclosure documents
Sector concentrationReview how a tilt toward pharmaceutical and biotech industries affects asset allocationSector concentrated
Distribution policyDistinguish between quarterly distributions and the possibility that payouts fluctuateRegular distributions
Currency effectReview how exchange rate movements affect returns in Korean won termsCurrency effect exists

Uncertainty in new drug development, changes in patent protection, generic drug competition, and policies on drug pricing and approvals can shift profitability expectations across the pharmaceutical industry. When market anxiety rises, it is also worth checking the gap between market price and net asset value for sector-specific products, as well as trading conditions.

The FTXH ETF is a product to consider if you want index-based exposure to the US pharmaceutical and biotech industries. However, it calls for an approach that understands its sector-concentrated structure, which differs from broad market products, does not interpret quarterly distributions as a guarantee of returns, and reviews regulatory, patent and currency risks within a long-term asset allocation.

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Disclaimer: This content is for informational purposes only and does not constitute investment advice. All investment responsibility lies with the investor.

This article reflects information as of August 17, 2026.

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